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Association Service off Actual Treatments and you may Treatment, Taipei Tzu Chi Medical, Buddhist Tzu Chi Medical Base, Brand new Taipei Urban area, Taiwan
Affiliations Office out of Rheumatology, Allergy, and you can Immunology, Institution away from Interior Drug, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Chang Gung University College off Treatments, Kaohsiung, Taiwan
Affiliations Chang Gung College or university University regarding Treatments, Kaohsiung, Taiwan, Agency off Obstetrics and you will Gynecology, Kaohsiung Chang Gung Art gallery Healthcare, Kaohsiung, Taiwan
Affiliations Department out of Rheumatology, Allergy, and you can Immunology, Company of Internal Medication, Kaohsiung Chang Gung Memorial Health, Kaohsiung, Taiwan, Chang Gung College or university University of Medication, Kaohsiung, Taiwan
- Fu-Mei Su,
- Dung-Huan Liu,
- Jia-Feng Chen,
- Shan-Fu Yu,
- Wen-Chan Chiu,
- Chung-Yuan Hsu,
Records
To cultivate an OSTAi product and you will examine which on the National Osteoporosis Base pointers in the 2013 (NOF 2013) to have limbs nutrient thickness (BMD) comparison certainly Taiwan postmenopausal lady.
Strategies
Taiwan Osteoporosis Relationship (TOA) presented a nationwide BMD survey by a coach installed which have an effective dual opportunity X-beam absorptiometry (DXA) ranging from 2008 and you may 2011. Most of the participants finished survey, including class and you can chance factors away from osteoporotic fracture when you look at the FRAX unit. I used the databases to research prospective exposure products to own osteoporosis and you can then followed brand new model from the Koh mais aussi al. to cultivate a risk list thru multiple variable regression data and product prevention. We utilized the index values to arrange a simple algorithm (particularly OSTAi) to determine those who you need BMD dimension. Individual functioning feature (ROC) bend together with town beneath the contour (AUC) was applied evaluate the fresh sensitiveness/specificity data for the design thereupon regarding suggestions because of the NOF 2013.
Performance
A maximum of a dozen,175 Taiwan postmenopausal women signed up for it questionnaire. The newest directory worthy of is derived by the years and body weight regarding the participants considering adjusted odds of per chance foundation and you will the brand new selected cutoff well worth is actually lay during the “-1”. You’ll find 6393 (52.5%) players whose index worth try less than “-1” and you may whose likelihood of osteoporosis is 57.5% (). New AUC getting OSTAi and you may NOF 2013 have been 0.739 (95% trust interval (CI), 0.728–0.749, P dos ), prior crack, high risk cures have fun with from the reduced bone size otherwise limbs losings (e.g., glucocorticoid within the a daily doses ? 5 milligrams prednisone or comparable to have ? three months), or state otherwise standing associated with bone losses (age.grams., rheumatoid arthritis). The latest symptomatic abilities away from NOF 2013 having predicting osteoporosis within our analyzed population ended up being reviewed.
Mathematical Study
I accompanied this new analytical analysis by Koh et al. with some amendment. The potential exposure affairs to have osteoporosis as part of the model innovation process consisted of the risk issues regarding the FRAX tool, in which ethnic grounds was not integrated.